Руны - это небольшие камешки с нанесенными на них магическимим символами. Они могут вставляться в сокетное оружие и доспехи. Наряду с Gems и Jewels, будучи вставлены в оружие или доспехи, руны передают свои свойства им, но это еще не всё. Существуют Магические комбинации(Rune Words), которые добавляют предметам еще магических свойств.

Рисунок	Название руны	Эффект для оружия	Эффект для доспехов (Armor/Helms/Shields)	Уровень героя
	El	+50 To Attack Rating, +1 Light Radius	+15 Defense, +1 To Light Radius	11
	Eld	175% Damage To Undead, +50 Attack Rating Against Undead	15% Stamina Drain/Increased Chance of Blocking(Shields)	11
	Tir	+2 To Mana After Each Kill	+2 To Mana After Each Kill	13
	Nef	Knockback	+30 Defense Vs. Missile	13
	Eth	-25% Target Defense	Regenerate Mana 15%	15
	Ith	+9 To Maximum Damage	15% Damage Taken Goes to Mana	15
	Tal	+19 Poison Damage Over 2 Seconds	Poison Resist 30%/Poison Resist 35%(Shields)	17
	Ral	Adds 5-30 Fire Damage	Fire Resist 30%/Fire Resist 35%(Shields)	19
	Ort	Adds 1-50 Lightning Damage	Lightning Resist 30%/Lightning Resist 35%(Shields)	21
	Thul	Adds 3-14 Cold Damage	Cold Resist 30%/Cold Resist 35%(Shields)	23
	Amn	7% Life Stolen Per Hit	Attacker Takes Damage of 14	25
	Sol	+9 To Minimum Damage	Damage Reduced By 7	27
	Shael	Increased Attack Speed	Faster Hit Recovery/Faster Block Rate(Shields)	29
	Dol	Hit Causes Monster To Flee 25%	Replenish Life +7	31
	Hel	Requirements -20%	Requirements -15%	33
	Io	+10 To Vitality	+10 To Vitality	35
	Lum	+10 To Energy	+10 To Energy	37
	Ko	+10 To Dexterity	+10 To Dexterity	39
	Fal	+10 To Strength	+10 To Strength	41
	Lem	75% Extra Gold From Monsters	50% Extra Gold From Monsters	43
	Pul	175% Damage To Demons, +100 Attack Rating Against Demons	+30% Enhanced Defense	45
	Um	25% Chance of Open Wounds	All Resistances +25(Armor) +15(Helms) +12(Shields)	47
	Mal	Prevent Monster Heal	Magic Damage Reduced By 7	49
	Ist	30% Better Chance of Getting Magic Items	25% Better Chance of Getting Magic Items	51
	Gul	20% Bonus To Attack Rating	5% To Maximum Poison Resist	53
	Vex	7% Mana Stolen Per Hit	5% To Maximum Fire Resist	55
	Ohm	+50% Enhanced Damage	5% To Maximum Cold Resist	57
	Lo	20% Deadly Strike	5% To Maximum Lightning Resist	59
	Sur	Hit Blinds Target	Maximum Mana 5%/+50 To Mana (Shields)	61
	Ber	20% Chance of Crushing Blow	Damage Reduced by 8%	63
	Jo	Slows Target By 25%	Increase Maximum Life 5%/+50 Life (Shields)	65
	Cham	Freeze Target	Cannot Be Frozen	67
	Zod	Indestructible	Indestructible	69